Vedroprevir
Vedroprevir (GS-9451) is an inhibitor for HCV NS3/4A protease with an IC50 of 3.2 nM. Vedroprevir is also an inhibitor for breast cancer resistant protein (BCRP) with an IC50 of 1.4 μM. Vedroprevir inhibits P-gp, MRP1 and MRP2 with IC50 of 34, 14.9 and 12 μM, respectively. Vedroprevir exhibits good pharmacokinetic characteristics in rats and dogs.
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- CAS No.: 1098189-15-1
- 화학식: C45H60ClN7O9S
- 분자량:910.52
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 3.2 nM (HCV NS3/4A protease), 1.4 μM (BCRP), 34 μM (P-gp), 14.9 μM (MRP1), 12 μM (MRP2)
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1098189-15-1
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분자량 910.52
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화학식 C45H60ClN7O9S
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SMILES
O=C([C@H]1N(C[C@@H](C1)OC2=CC(C3=CSC(NC(C)C)=N3)=NC4=C2C=CC(OCCN5CCOCC5)=C4Cl)C([C@H](C(C)(C)C)NC(O[C@H]6C[C@]7([H])[C@](C7)([H])C6)=O)=O)N[C@]8([C@@H](C8)CC)C(O)=O
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Synonyms
GS-9451
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Vedroprevir Related Classifications
HY-16773 Related Classifications
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