L-Glutathione reduced-d₅ ammonium  (Synonyms: GSH-d5 ammonium; γ-L-Glutamyl-L-cysteinyl-glycine-d5 ammonium)

L-Glutathione reduced-d₅ (GSH-d₅) ammonium is the deuterium labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

312.35 (free base)

C₁₀H₁₂D₅N₃O₆S.xNH₃

Solid

White to off-white

O=C(CNC([C@@H](NC(C([2H])(C([2H])([C@](N)(C(O)=O)[2H])[2H])[2H])=O)CS)=O)O.N.[x]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Pereira-Rodrigues N, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry. 2007 Jan;70(1):147-54.  [Content Brief]