Secosteroids

Brassicasteryl linoleate is a cholinesterase inhibitor. Brassicasteryl linoleate inhibits acetylcholinesterase, butyrylcholinesterase and urease. Brassicasteryl linoleate inhibits lipid peroxidation. Brassicasteryl linoleate is applicable to research related to breast cancer, lung cancer and colon adenocarcinoma.

Campesteryl linoleate is a phytosterol fatty acid ester formed by the esterification of campesterol and linoleic acid. It is found in grains such as corn, rye, wheat and spelt, and is one of the major unsaturated fatty acid sterol esters in corn. Campesteryl linoleate can be used in studies related to phytosterol metabolism, grain lipid composition and kernel black point.

Progenin II is a steroidal saponin found in the rhizomes of Dioscorea panthaica.

Conicasterol is a 4-mercaptosteroid with significant cytotoxic activity. Conicasterol showed an IC50 value of 6.23 μg/mL in a test on a human breast adenocarcinoma cell line (MCF-7). Conicasterol's antitumor activity makes it a potential bioactive lead molecule.

(7β,22E)-7,8-Epoxyergosta-4,22-diene-3,6-dione (Compound 1) is a steroidal compound. It can be extracted from Ganoderma lingzhi. (7β,22E)-7,8-Epoxyergosta-4,22-diene-3,6-dione exhibits anticancer activity against non-small cell lung cancer and breast cancer.

Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research.

22-Oxo-20-hydroxyecdysone is a phytoecdysteroid, found in Serratula tinctoria (Asteraceae). 22-Oxo-20-hydroxyecdysone triggers supernumerary moulting and leg, mouth part malformations in Ornithodoros moubata females.

Dacryhainansterone is an insect ecdysteroid receptor agonist with a pIC₅₀ of 7.64 M.Dacryhainansterone binds to the insect ecdysteroid receptor and activates it in a reporter gene assay.

BbGL-1 is a glycosylated sterol lipid containing saturated acyl chains.

Penasterol is an active compound.

5β-Hydroxybufotalin (compound 6) is an anticancer agent that can effectively inhibit the growth activity of cancer cells. 5β-Hydroxybufotalin is also a natural product obtained from the chinese traditional drug Ch'an Su.

Scillaren A is a cardiac glycoside, can be isolated from the bulbs of D. coromandeliana.

18:1 stigmasteryl glucose is a glycosylated sterol.

CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection.

19-nor-1α,25-Dihydroxyvitamin D3 is a vitamin D receptor (VDR) agonist with an EC₅₀ of 4.8 nM. 19-nor-1α,25-Dihydroxyvitamin D3 binds to VDR and promotes gene transcription. 19-nor-1α,25-Dihydroxyvitamin D3 can be used in the research of diseases related to the vitamin D signaling pathway.

24-Oxo-25-hydroxyvitamin D3 is a vitamin D3 metabolite and an intermediate in the renal mitochondrial side-chain oxidation pathway. 24-Oxo-25-hydroxyvitamin D3 enhances intestinal calcium transport in rats. 24-Oxo-25-hydroxyvitamin D3 can be used in studies related to X-linked hypophosphatemic rickets.

1α,25-Dihydroxy-24-oxocholecalciferol is the C-24 oxidative metabolite of 1,25-dihydroxycholecalciferol.

Ro 23-7553 is a mitochondrial inhibitor. Ro 23-7553 promotes chondrocyte differentiation at physiological concentrations, while supraphysiological concentrations inhibit both proliferation and differentiation. Ro 23-7553 can be used for the study of cancer.

Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is a metabolite of vitamin D3. Calcitriol lactone is the active form of vitamin D and affects bone health, cell differentiation, immune function.