Secosteroids

Calcitriol Derivatives is a vitamin D3 analog.

Chlorogenin is a natural product that can be isolated from the flowers of Agave americana.

Methyl protogracillin (NSC-698793), isolated from the roots of Dioscorea opposite Thunb, exhibits strong anti-cancer activity.

(R)-Vitamin D2 is the isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.

Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism.

trans-Doxercalciferol is an isomer of Doxercalciferol (HY-32348). Doxercalciferol is a vitamin D receptor agonist. Doxercalciferol reduces proteinuria, podocyte injury, mesangial expansion, extracellular matrix accumulation, macrophage infiltration, oxidative stress, proinflammatory cytokines, profibrotic growth factors, renal neutral lipid accumulation, albuminuria and glomerulosclerosis. Doxercalciferol alleviates high-salt diet-induced myocardial hypertrophy. trans-Doxercalciferol is used for the research of diet-induced obesity-related nephropathy, diabetic nephropathy, myocardial hypertrophy, cardiac dysfunction and secondary hyperparathyroidism.

Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

MC 1046 (Impurity A of Calcipotriol) is a hepatic metabolite and an impurity of Calcipotriol (HY-10001). MC 1046 induces differentiation of histiocytic lymphoma cells. MC 1046 can be used for the research of histiocytic lymphoma.

7β,25-Dihydroxycholesterol is an endogenous metabolite and is found to act as chemoattractants for immune cells expressing EBI2.

Digitalin (Digitalinum verum) is a cardiac glycoside and can be isolated from Digitalis.

Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

Impurity B of Calcitriol is a diastereomer of 1α,25-dihydroxyvitamin D₃ that interferes with accurate Calcitriol quantification.

(1R,5Z)-Calcitriol ((1R,5Z)-1,25-Dihydroxyvitamin D3) is a Calcitriol (HY-10002) isomer. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

Sitoindoside II is a chemopreventive agent that induces HL-60 cell differentiation (ED₅₀: 69 nM). Sitoindoside II can be isolated from the ethanol extract of whole plants of Munronia delavayi.

Sengosterone is a steroid and can be isolated from Ajuga remota.

Brassicasteryl linoleate is a cholinesterase inhibitor. Brassicasteryl linoleate inhibits acetylcholinesterase, butyrylcholinesterase and urease. Brassicasteryl linoleate inhibits lipid peroxidation. Brassicasteryl linoleate is applicable to research related to breast cancer, lung cancer and colon adenocarcinoma.

Campesteryl linoleate is a phytosterol fatty acid ester formed by the esterification of campesterol and linoleic acid. It is found in grains such as corn, rye, wheat and spelt, and is one of the major unsaturated fatty acid sterol esters in corn. Campesteryl linoleate can be used in studies related to phytosterol metabolism, grain lipid composition and kernel black point.

Progenin II is a steroidal saponin found in the rhizomes of Dioscorea panthaica.

Conicasterol is a 4-mercaptosteroid with significant cytotoxic activity. Conicasterol showed an IC50 value of 6.23 μg/mL in a test on a human breast adenocarcinoma cell line (MCF-7). Conicasterol's antitumor activity makes it a potential bioactive lead molecule.