Lurasidone-d8-1 hydrochloride
Based on 1 Customer Validation
Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
For research use only. We do not sell to patients.
- Formula: C28H29D8ClN4O2S
- Molecular Weight:537.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT1A Receptor |
5-HT7 Receptor |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 367514-88-3
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Molecular Weight 537.19
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Formula C28H29D8ClN4O2S
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SMILES
[H][C@]12C[C@@]([H])(CC2)[C@@]3([H])[C@]1([H])C(N(C3=O)C[C@@H]4CCCC[C@H]4CN5C([2H])(C([2H])(N(C([2H])(C5([2H])[2H])[2H])C6=NSC7=C6C=CC=C7)[2H])[2H])=O.Cl
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Synonyms
SM-13496-d8-1 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 6.67 mg/mL (12.42 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 2 mg/mL (3.72 mM; Need ultrasonic)
H2O : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 80°C)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[3]. Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Ethanol / DMSO | 1 mM | 1.8615 mL | 9.3077 mL | 18.6154 mL | 46.5385 mL |
| DMSO | 5 mM | 0.3723 mL | 1.8615 mL | 3.7231 mL | 9.3077 mL |
| 10 mM | 0.1862 mL | 0.9308 mL | 1.8615 mL | 4.6538 mL |
Lurasidone-d8-1 hydrochloride Related Classifications
HY-W654010 Related Classifications
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