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製品番号: HY-187797

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Luxafimloc

Name: Luxafimloc
Brand: MedChemExpress
SKU: HY-187797
Availability: PreOrder

(別名: GSK3882347)

Luxafimloc (GSK3882347) is a FimH inhibitor and anti-infective agent. Luxafimloc inhibits the activity of the FimH adhesin molecule. Luxafimloc reduces the bacterial load in the bladder of mice with acute cystitis induced by Klebsiella pneumoniae infection. Luxafimloc can be used in studies related to urinary tract infections, including cystitis, uncomplicated urinary tract infection, complicated urinary tract infection, catheter-associated urinary tract infection, acute urinary tract infection, recurrent urinary tract infection, and chronic urinary tract infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2408524-70-7
分子式: C₂₀H₂₂F₂O₆
分子量:396.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Luxafimloc 構造式

CAS 番号: 2408524-70-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Bacterial Infection

Luxafimloc (Compound I) (50 mg/kg; subcutaneous injection; once every 12 hours; 2 doses total) reduces the bacterial load in the bladders of mice with acute cystitis induced by Klebsiella pneumoniae strains TOP52, JMI-57, JMI-64, JMI-75, JMI-82, and JMI-92 by ≥2-Log₁₀^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HeN (female, 7-9 weeks old, specific pathogen free, transurethrally inoculated with Klebsiella pneumoniae strain TOP52, JMI-57, JMI-64, JMI-75, JMI-82, JMI-92)^[1]
Dosage:

50 mg/kg
Administration:

s.c.; q12h; two doses
Result:

Achieved a ≥2-Log₁₀ drop in bladder bacterial CFU counts from pre-treatment baseline and vehicle control levels at 48 hours post initial infection.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 2408524-70-7
分子量 396.38
分子式 C₂₀H₂₂F₂O₆
SMILES

O[C@H](C1=C(C=C(C2=CC(F)=CC(F)=C2)C=C1)C)[C@@]3([H])O[C@@H]([C@H]([C@@H]([C@@H]3O)O)O)CO
別名

GSK3882347
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. ABRAHAM, Nabil Mathew, et al. Method for the treatment or prevention of infections caused by Klebsiella bacteria. W02026/077990 A1. 2026-04-16.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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