2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. LY-311727

LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme.

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LY-311727

LY-311727 Estructura química

No. CAS : 164083-84-5

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LY-311727 Related Antibodies

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Descripciòn

LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme[1][2].

IC50 & Target

sPLA2[1]
In Vitro

LY-311727 (0.1-10 μM) suppresses the contractile responses induced by human non-pancreatic secretory phospholipase A2 (hnps-PLA2), in a concentration related manner[1].
LY-311727 nearly abolishes the hnps-PLA2 responses at 1 μM, while it failed to suppress porcine pancreatic PLA2 concentration response curves at the same concentration[1].
LY-311727 displays 1,500-fold selectivity when assayed against porcine pancreatic s-PLA2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY-311727 Related Antibodies
In Vivo

LY-311727 (3-30 mg/kg; i.v.) dramatically suppresses the circulating enzyme activity in mice with metallothionein promoter-human secretory PLA2 minigene (Mt-sPLA2) transgenic the intravenous (i.v.) administration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice, Mt-sPLA2 transgenic mice model[2]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Intravenous injection
Result: Significantly and dose dependently suppressed the PLA2 activity in the serum.
Peso molecular

430.43

Fòrmula

C22H27N2O5P
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

NC(CC1=C(CC)N(CC2=CC=CC=C2)C3=C1C=C(OCCCP(O)(O)=O)C=C3)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : ≥ 30 mg/mL (69.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3233 mL 11.6163 mL 23.2326 mL
5 mM 0.4647 mL 2.3233 mL 4.6465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.73%

SDS (251 KB)

COA (246 KB) HNMR (286 KB) LCMS (315 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3233 mL 11.6163 mL 23.2326 mL 58.0815 mL
5 mM 0.4647 mL 2.3233 mL 4.6465 mL 11.6163 mL
10 mM 0.2323 mL 1.1616 mL 2.3233 mL 5.8081 mL
15 mM 0.1549 mL 0.7744 mL 1.5488 mL 3.8721 mL
20 mM 0.1162 mL 0.5808 mL 1.1616 mL 2.9041 mL
25 mM 0.0929 mL 0.4647 mL 0.9293 mL 2.3233 mL
30 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9360 mL
40 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.4520 mL
50 mM 0.0465 mL 0.2323 mL 0.4647 mL 1.1616 mL
60 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9680 mL
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LY-311727 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY-311727164083-84-5LY311727LY 311727Phospholipasesecretoryenzymenon-pancreaticphospholipaseA2proinflammatoryInhibitorinhibitorinhibit

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Nombre del producto:
LY-311727
Cat. No.:
HY-107393
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