Macotirom
Macotirom is a thyroid hormone β receptor agonist. Macotirom can be used in studies related to metabolic diseases and the liver.
For research use only. We do not sell to patients.
- CAS No.: 2673409-79-3
- Formula: C19H15Cl2F2N5O7S
- Molecular Weight:566.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Thyroid hormone β receptor is a member of the nuclear receptor family, which mediates the nuclear translocation of T3 to regulate the transcription of target genes and governs physiological effects such as body metabolism, development and heart rate.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2673409-79-3
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Molecular Weight 566.32
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Formula C19H15Cl2F2N5O7S
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SMILES
O=C1N(N=C(C(N1)=O)C(F)F)C2=CC(Cl)=C(C(Cl)=C2)OC3=CC(S(N[C@H]4C[C@@H](C4)O)(=O)=O)=C(C=N3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Macotirom Related Classifications
HY-187798 Related Classifications
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