MAO-A-IN-5
MAO-A-IN-5 (compound 4g) is a selective human monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.250 μM against MAO-A. MAO-A-IN-5 competitively inhibits the activity of MAO enzymes, impedes the metabolism of neurotransmitter amines, and potentially reduces hydrogen peroxide produced by the MAO-catalyzed cycle. MAO-A-IN-5 can be used for research on Parkinson's disease and depression.
For research use only. We do not sell to patients.
- CAS No.: 1898180-94-3
- Formula: C16H9ClN2O2
- Molecular Weight:296.71
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
MAO-A 0.250 μM (IC50) |
MAO-B > 100 μM (IC50) |
In Vitro
MAO-A-IN-5 (compound 4g) (0.003-100 μM) potently and selectively inhibits recombinant human MAO-A with an IC50 of 0.250 μM, whereas it exhibits no detectable inhibitory activity against recombinant human MAO-B at concentrations up to 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 1898180-94-3
-
Molecular Weight 296.71
-
Formula C16H9ClN2O2
-
SMILES
ClC1=C(C2=CC=CC=C2)NC3=CC4=C(C(NC4=O)=O)C=C31
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
-
Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-A-IN-5 Related Classifications
HY-186306 Related Classifications
Powered by Bioz