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Art. -Nr.: HY-184503

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MAO-B-IN-59

MAO-B-IN-59 is a reversible, selective competitive inhibitor of MAO-B, with an IC₅₀ of 0.082 μM against human MAO-B, and exhibits moderate blood-brain barrier permeability. MAO-B-IN-59 can be used in the research of Parkinson's disease.

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CAS. Nr.: 1163744-36-2
Formel: C₁₇H₁₁ClO₂
Molecular Weight:282.72

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAO-B-IN-59 Chemical Structure

CAS. Nr.: 1163744-36-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Beschreibung

IC₅₀ & Target

^[1]

hMAO-B

82 nM (IC₅₀)

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen :

MAO-A
MAO-B

In Vitro

MAO-B-IN-59 (BF2) (0.1-0.17 μM; 0-30 min) acts as a reversible inhibitor of recombinant human MAO-B, with no time-dependent binding and activity recovery after dialysis consistent with reversible inhibition^[1].

MAO-B-IN-59 (6.25-100 μg/mL) is non-cytotoxic to mouse fibroblast L929 cells at concentrations up to 25 μg/mL, with an IC₅₀ of 55.84 μg/mL (197.51 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 1163744-36-2
Molecular Weight 282.72
Formel C₁₇H₁₁ClO₂
SMILES

O=C(C1=CC2=CC=CC=C2O1)/C=C/C3=CC=CC=C3Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hasan A, et al. Development of 1-(substituted benzofuran-2-yl)-3-(halogen-substituted phenyl)prop-2-en-1-ones as potent, reversible, and selective MAO-B inhibitors for Parkinson's Disease. Scientific reports. 2026 Jun 03. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MAO-B-IN-59

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen

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IC50 & Target

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Chemical Information

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MAO-B-IN-59 Related Classifications

HY-184503 Related Classifications

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