Maritinone
Maritinone is a compound with antiproliferative activity and exhibits strong cytostatic activity in various tumor cell lines.
For research use only. We do not sell to patients.
- CAS No.: 33927-59-2
- Formula: C22H14O6
- Molecular Weight:374.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ACHN | EC50 |
1.5 μM
Compound: 4
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Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay
Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay
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[PMID: 22313254] |
| ACHN | EC50 |
5.8 μM
Compound: 4
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Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL
Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL
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[PMID: 22313254] |
| HUVEC | ED50 |
2.2 μg/mL
Compound: 2
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Cytotoxicity against human HUVEC
Cytotoxicity against human HUVEC
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[PMID: 15270571] |
| KB | ED50 |
0.3 μg/mL
Compound: 2
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 15270571] |
| LNCaP | ED50 |
2.2 μg/mL
Compound: 2
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 15270571] |
| Lu1 | ED50 |
1.4 μg/mL
Compound: 2
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Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
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[PMID: 15270571] |
Chemical Information
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CAS No. 33927-59-2
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Molecular Weight 374.34
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Formula C22H14O6
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SMILES
O=C1C=C(C)C(C2=C(C3=CC=C(C(C(C=C4C)=O)=C3C4=O)O)C=CC(O)=C12)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Maritinone Related Classifications
HY-114639 Related Classifications
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