1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MC-Sq-Cit-PAB-Dolastatin10

MC-Sq-Cit-PAB-Dolastatin10 

Cat. No.: HY-128894
Handling Instructions

MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.

For research use only. We do not sell to patients.

MC-Sq-Cit-PAB-Dolastatin10 Chemical Structure

MC-Sq-Cit-PAB-Dolastatin10 Chemical Structure

CAS No. : 1941168-65-5

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Description

MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.

IC50 & Target

Auristatin

 

In Vitro

ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.385 nM, and ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC50s of 3.19 nM, 1.52 nM, respectively[1].

Molecular Weight

1338.72

Formula

C₇₀H₁₀₅N₁₂O₁₂S

CAS No.

1941168-65-5

SMILES

C[N+]([[email protected]](C(N[[email protected]](C(N([[email protected]@H]([[email protected]@H](C)CC)[[email protected]](OC)CC(N1[[email protected]]([[email protected]](OC)[[email protected]@H](C)C(N[[email protected]](C2=NC=CS2)CC3=CC=CC=C3)=O)CCC1)=O)C)=O)C(C)C)=O)C(C)C)(CC4=CC=C(NC([[email protected]@H](NC(C5(C(NCCCCCN6C(C=CC6=O)=O)=O)CCC5)=O)CCCNC(N)=O)=O)C=C4)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MC-Sq-Cit-PAB-Dolastatin10
Cat. No.:
HY-128894
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