MC-VA-PAB-Exatecan

Name: MC-VA-PAB-Exatecan
Brand: MedChemExpress
SKU: HY-147270
Rating: 4.5 (1 reviews)

製品番号: HY-147270 純度: 98.88%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

MC-VA-PAB-Exatecan 構造式

CAS 番号 : 2680543-57-9

容量	価格（税別）	在庫状況	数量
5 mg	$350	在庫あり	Estimated Time of Arrival: December 31
10 mg	$520	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Patent. US20250255982A1.

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Topoisomerase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Topoisomerase Topo I Topo II DNA gyrase

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Camptothecins

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

948.00

分子式

C₅₀H₅₄FN₇O₁₁

CAS 番号

2680543-57-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMF : ≥ 100 mg/mL (105.49 mM)

DMSO : 100 mg/mL (105.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0549 mL	5.2743 mL	10.5485 mL
5 mM	0.2110 mL	1.0549 mL	2.1097 mL
10 mM	0.1055 mL	0.5274 mL	1.0549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.01%

Select Batch:

データシート (276 KB) SDS (252 KB)

COA (258 KB) HNMR (574 KB) LCMS (102 KB)

取扱説明書 (2659 KB)

参考文献

[1]. KRAIEM, et al. Treatment of cancer. WO2021151984A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMSO	1 mM	1.0549 mL	5.2743 mL	10.5485 mL	26.3713 mL
	5 mM	0.2110 mL	1.0549 mL	2.1097 mL	5.2743 mL
	10 mM	0.1055 mL	0.5274 mL	1.0549 mL	2.6371 mL
	15 mM	0.0703 mL	0.3516 mL	0.7032 mL	1.7581 mL
	20 mM	0.0527 mL	0.2637 mL	0.5274 mL	1.3186 mL
	25 mM	0.0422 mL	0.2110 mL	0.4219 mL	1.0549 mL
	30 mM	0.0352 mL	0.1758 mL	0.3516 mL	0.8790 mL
	40 mM	0.0264 mL	0.1319 mL	0.2637 mL	0.6593 mL
	50 mM	0.0211 mL	0.1055 mL	0.2110 mL	0.5274 mL
	60 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.4395 mL
	80 mM	0.0132 mL	0.0659 mL	0.1319 mL	0.3296 mL
	100 mM	0.0105 mL	0.0527 mL	0.1055 mL	0.2637 mL