2. Apoptosis
  3. MDM-2/p53
  4. MDM2-IN-21

MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.

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MDM2-IN-21

MDM2-IN-21 화학구조

CAS No. : 939981-88-1

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MDM2-IN-21 Related Antibodies

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제품 설명

MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer[1].

IC50 & Target

MDM2[1]
Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
1.2 μM
Compound: 2b
Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
MDA-MB-435 IC50
4.2 μM
Compound: 2b
Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
RKO IC50
0.5 μM
Compound: 2b
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
SJSA-1 IC50
0.6 μM
Compound: 2b
Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
SW480 IC50
2.7 μM
Compound: 2b
Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
In Vitro

The IC50 values of MDM2-IN-21 are 0.03 μM and 0.8 μM in homogeneous time resolved fluorescence (HTRF) assay and the wild-type p53 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2-IN-21 Related Antibodies
분자량

607.61

화학식

C34H40Cl2N4O2
CAS No.
SMILES

C[C@]1(C2=CC=C(C=C2)Cl)N(C(C3=C(C=C(C=C3)C(C)(C)C)OCC)=N[C@]1(C4=CC=C(C=C4)Cl)C)C(N5CCNCC5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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MDM2-IN-21 Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-IN-21939981-88-1MDM-2/p53potentcancertumorHTRFwild-typep53Inhibitorinhibitorinhibit

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상품명:
MDM2-IN-21
Cat. No.:
HY-139458
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