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Cat. No.: HY-W024615

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Me-diazirine-cooh

(Synonyms: 3-(3-Methyl-3H-diazirin-3-yl)propanoic acid)

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Me-diazirine-cooh (3-(3-Methyl-3H-diazirin-3-yl) propanoic acid) is a molecular building block containing an aliphatic diazirine ring. Me-diazirine-cooh undergoes orthogonal coupling in solid-phase peptide synthesis to introduce the Diazirine group into collagen-mimetic peptides. Me-diazirine-cooh is used to construct the photoaffinity probe P1.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 25055-86-1
Formula: C₅H₈N₂O₂
Molecular Weight:128.13

Storage:

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Me-diazirine-cooh Chemical Structure

CAS No.: 25055-86-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Me-diazirine-cooh enables orthogonal coupling in solid-phase peptide synthesis, thereby introducing the Diazirine group into collagen-mimetic peptides^[1].
Me-diazirine-cooh can be used to construct the photoaffinity probe P1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 25055-86-1
Appearance Liquid (Density: 1.38±0.1 g/cm³)
Molecular Weight 128.13
Formula C₅H₈N₂O₂
Color Light yellow to brown
SMILES

CC1(CCC(=O)O)N=N1
Synonyms

3-(3-Methyl-3H-diazirin-3-yl)propanoic acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (628 KB)
- English - EN (628 KB)
- Français - FR (628 KB)
- Deutsch - DE (628 KB)
- Norwegian - NO (628 KB)
- Español - ES (628 KB)
- Swedish - SV (628 KB)
- Italian - IT (628 KB)
- Korean - KR (628 KB)
- Portuguese - PT (628 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Castillo Orenes M. Development of a Bone Adhesive Material based on Diazirinyl-Collagen Mimetic Peptides[J]. 2025.

[2]. Li H, et al. Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders. J Med Chem. 2022;65(10):7154-7169. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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