Mepazine acetate
Based on 2 publication(s) in Google Scholar
Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1. Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL)-induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin. The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies.
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- CAS No.: 24360-97-2
- Formula: C21H26N2O2S
- Molecular Weight:370.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Mepazine acetate
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Biological Activity
Chemical Information
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CAS No. 24360-97-2
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Molecular Weight 370.51
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Formula C21H26N2O2S
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SMILES
O=C(C)O.CN(CCC1)CC1CN2C3=C(C=CC=C3)SC4=C2C=CC=C4
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Synonyms
Pecazine acetate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Blood
2022 Sep 29;140(13):1549-1564. PMID: 35895897 -
Int J Mol Sci
Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. [Abstract]2023 Apr 17;24(8):7402. PMID: 37108564
Purity & Documentation
References
[1]. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37. [Content Brief]
[2]. Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mepazine acetate Related Classifications
HY-121282B Related Classifications
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