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Cat. No.: HY-107749R

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ML 190 (Standard)

ML 190 (Standard) is the analytical standard of ML 190 (HY-107749). This product is intended for research and analytical applications. ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC₅₀ of 120 nM and an EC₅₀ of 129 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1355244-02-8
Formula: C₂₇H₃₂N₆O₃
Molecular Weight:488.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ML 190 (Standard) Chemical Structure

CAS No.: 1355244-02-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC₅₀: 120 nM (KOR)^[1]
EC₅₀: 129 nM (KOR)^[1]

All Opioid Receptor Isoforms :

Chemical Information

CAS No. 1355244-02-8
Molecular Weight 488.58
Formula C₂₇H₃₂N₆O₃
SMILES

O=C1C2=CC=CN2C3=C(C)C=CN=C3N1CC(NCCCN4CCN(CC4)C5=CC=C(C=C5)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Frankowski KJ, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci. 2012;3(3):221-236. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

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ML 190 (Standard)

All Opioid Receptor Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

ML 190 (Standard) Related Classifications

HY-107749R Related Classifications

Bioz

Keywords

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