ML261
Based on 1 Customer Validation
ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 902523-58-4
- Formula: C20H23ClN2O3S
- Molecular Weight:406.94
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 69.7 nM (hepatic lipid droplets formation)[1]
ML261 (1 nM-10 μM; 24 h) affects hepatic lipid droplets formation in murine AML-12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML-12 cells
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Concentration:1 nM-10 μM
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Incubation Time:24 hours
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Result:Inhibited hepatic lipid droplets formation with an IC50 value of 69.7 nM.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 902523-58-4
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Appearance Solid
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Molecular Weight 406.94
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Formula C20H23ClN2O3S
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Color White to off-white
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SMILES
O=C(C1=CC2=C(C=C(Cl)S2)N1C)NCCC3=CC=C(OCC)C(OCC)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (61.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4574 mL | 12.2870 mL | 24.5739 mL | 61.4349 mL |
| 5 mM | 0.4915 mL | 2.4574 mL | 4.9148 mL | 12.2870 mL | |
| 10 mM | 0.2457 mL | 1.2287 mL | 2.4574 mL | 6.1435 mL | |
| 15 mM | 0.1638 mL | 0.8191 mL | 1.6383 mL | 4.0957 mL | |
| 20 mM | 0.1229 mL | 0.6143 mL | 1.2287 mL | 3.0717 mL | |
| 25 mM | 0.0983 mL | 0.4915 mL | 0.9830 mL | 2.4574 mL | |
| 30 mM | 0.0819 mL | 0.4096 mL | 0.8191 mL | 2.0478 mL | |
| 40 mM | 0.0614 mL | 0.3072 mL | 0.6143 mL | 1.5359 mL | |
| 50 mM | 0.0491 mL | 0.2457 mL | 0.4915 mL | 1.2287 mL | |
| 60 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0239 mL |
ML261 Related Classifications
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