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ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation.

For research use only. We do not sell to patients.

ML261 Chemical Structure

ML261 Chemical Structure

CAS No. : 902523-58-4

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1 mg USD 120 In-stock
5 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation[1].

IC50 & Target

IC50: 69.7 nM (hepatic lipid droplets formation)[1]

In Vitro

ML261 (1 nM-10 μM; 24 h) affects hepatic lipid droplets formation in murine AML-12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AML-12 cells
Concentration: 1 nM-10 μM
Incubation Time: 24 hours
Result: Inhibited hepatic lipid droplets formation with an IC50 value of 69.7 nM.
Molecular Weight

406.93

Formula

C20H23ClN2O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(C=C(Cl)S2)N1C)NCCC3=CC=C(OCC)C(OCC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (61.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4574 mL 12.2871 mL 24.5743 mL
5 mM 0.4915 mL 2.4574 mL 4.9149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.80%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4574 mL 12.2871 mL 24.5743 mL 61.4356 mL
5 mM 0.4915 mL 2.4574 mL 4.9149 mL 12.2871 mL
10 mM 0.2457 mL 1.2287 mL 2.4574 mL 6.1436 mL
15 mM 0.1638 mL 0.8191 mL 1.6383 mL 4.0957 mL
20 mM 0.1229 mL 0.6144 mL 1.2287 mL 3.0718 mL
25 mM 0.0983 mL 0.4915 mL 0.9830 mL 2.4574 mL
30 mM 0.0819 mL 0.4096 mL 0.8191 mL 2.0479 mL
40 mM 0.0614 mL 0.3072 mL 0.6144 mL 1.5359 mL
50 mM 0.0491 mL 0.2457 mL 0.4915 mL 1.2287 mL
60 mM 0.0410 mL 0.2048 mL 0.4096 mL 1.0239 mL
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ML261 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ML261
Cat. No.:
HY-111179
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