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  3. ML338

ML338 

Cat. No.: HY-136348
Handling Instructions

ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy.

For research use only. We do not sell to patients.

ML338 Chemical Structure

ML338 Chemical Structure

CAS No. : 1630160-25-6

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Description

ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy[1].

IC50 & Target

IC90: 1 μM (non-replicating Mycobacterium tuberculosis bacilli)
IC99: 4 μM (non-replicating Mycobacterium tuberculosis bacilli)

In Vitro

ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC90 of 1 μM. Additionally, ML338 have an IC99 against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs[1].
ML338  (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration[1].
ML338 is against the non-replicating M. tuberculosis with IC90 and IC99 velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC90 and IC99 velues of 62 μM and 62 μM, respectively by CFU[1].

Molecular Weight

369.83

Formula

C₁₇H₁₂ClN₅OS

CAS No.

1630160-25-6

SMILES

ClC1=CC=C(C2=NN=C(SCC3=CN(C4=CC=CC=C4)N=N3)O2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ML338ML 338ML-338BacterialeukaryotichostcellsHEK293HepG2HeLaM. tuberculosisnutrientdeprivationTB chemotherapyInhibitorinhibitorinhibit

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