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Cat. No.: HY-136112

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N-Succinimidyl acetate

(Synonyms: Succinimidyl acetate; Ac-OSu)

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N-Succinimidyl acetate (Succinimidyl acetate; Ac-OSu) is a bioconjugation and peptide synthesis reagent. N-Succinimidyl acetate performs acetylation modification on the N-terminus and lysine side chains of proteins. N-Succinimidyl acetate is applicable to research fields including protein labeling, vaccine development and targeted drug delivery.

For research use only. We do not sell to patients.

CAS No.: 14464-29-0
Formula: C₆H₇NO₄
Molecular Weight:157.12

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

N-Succinimidyl acetate Chemical Structure

CAS No.: 14464-29-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

N-Succinimidyl acetate (250 μM; 5 min) acetylates ¹³C/¹⁵N-enriched α-synuclein at the N-terminal methionine and lysine side chains in vitro, yielding ~10% acetylation of the protein population^[1].
N-Succinimidyl acetate (250 μM; 5 min) acetylates ¹³C/¹⁵N-enriched ubiquitin at the N-terminal methionine and lysine side chains in vitro, yielding ~10% acetylation of the protein population^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 14464-29-0
Appearance Solid
Molecular Weight 157.12
Formula C₆H₇NO₄
Color White to off-white
SMILES

O=C(CC1)N(OC(C)=O)C1=O
Synonyms

Succinimidyl acetate; Ac-OSu
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee K, et al. Selective detection of protein acetylation by NMR spectroscopy. Journal of magnetic resonance (San Diego, Calif. : 1997). 2022 Apr;337:107169. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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