Bromonitromethane
Based on 1 Customer Validation
Bromonitromethane is a halonitromethane that can be used in production of various protected α-bromo nitroalkane donors for use in Umpolung Amide Synthesis (UmAS).
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 563-70-2
- Formula: CH2BrNO2
- Molecular Weight:139.94
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
38 μM
Compound: 4
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Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method
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[PMID: 23266177] |
| Calu-6 | IC50 |
23 μM
Compound: 4
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Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method
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[PMID: 23266177] |
| CAPAN-1 | IC50 |
69 μM
Compound: 4
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Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method
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[PMID: 23266177] |
| Ca-Ski | IC50 |
99 μM
Compound: 4
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Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method
Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method
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[PMID: 23266177] |
| HaCaT | IC50 |
25 μM
Compound: 4
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Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method
Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method
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[PMID: 23266177] |
| MeWo | IC50 |
40 μM
Compound: 4
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Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method
Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method
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[PMID: 23266177] |
Chemical Information
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CAS No. 563-70-2
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Appearance Liquid (Density: 1.971±0.06 g/cm3)
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Molecular Weight 139.94
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Formula CH2BrNO2
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Color Colorless to light yellow
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SMILES
O=[N+](CBr)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (714.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (549 KB)
- English - EN (549 KB)
- Français - FR (549 KB)
- Deutsch - DE (549 KB)
- Norwegian - NO (549 KB)
- Español - ES (549 KB)
- Swedish - SV (549 KB)
- Italian - IT (549 KB)
- Korean - KR (549 KB)
- Portuguese - PT (549 KB)
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Handling Instructions (2659 KB)
References
[1]. Dawn M Makley, et al. Silyl Imine Electrophiles in Enantioselective Catalysis: A Rosetta Stone for Peptide Homologation, Enabling Diverse N-protected Aryl Glycines From Aldehydes in Three Steps. Org Lett. 2014 Jun 6;16(11):3146-9. [Content Brief]
[2]. Alicia Marsà, et al. In Vitro Studies on the Tumorigenic Potential of the Halonitromethanes Trichloronitromethane and Bromonitromethane. Toxicol In Vitro. 2017 Dec;45(Pt 1):72-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.1459 mL | 35.7296 mL | 71.4592 mL | 178.6480 mL |
| 5 mM | 1.4292 mL | 7.1459 mL | 14.2918 mL | 35.7296 mL | |
| 10 mM | 0.7146 mL | 3.5730 mL | 7.1459 mL | 17.8648 mL | |
| 15 mM | 0.4764 mL | 2.3820 mL | 4.7639 mL | 11.9099 mL | |
| 20 mM | 0.3573 mL | 1.7865 mL | 3.5730 mL | 8.9324 mL | |
| 25 mM | 0.2858 mL | 1.4292 mL | 2.8584 mL | 7.1459 mL | |
| 30 mM | 0.2382 mL | 1.1910 mL | 2.3820 mL | 5.9549 mL | |
| 40 mM | 0.1786 mL | 0.8932 mL | 1.7865 mL | 4.4662 mL | |
| 50 mM | 0.1429 mL | 0.7146 mL | 1.4292 mL | 3.5730 mL | |
| 60 mM | 0.1191 mL | 0.5955 mL | 1.1910 mL | 2.9775 mL | |
| 80 mM | 0.0893 mL | 0.4466 mL | 0.8932 mL | 2.2331 mL | |
| 100 mM | 0.0715 mL | 0.3573 mL | 0.7146 mL | 1.7865 mL |
Bromonitromethane Related Classifications
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