LPPM-8
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology.
For research use only. We do not sell to patients.
- Formula: C50H89N7O14
- Molecular Weight:1012.28
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Med25 is a substoichiometric component of the megadalton Mediator complex and serves to bridge Mediator and transcriptional activators during transcription initiation through PPIs with the amphipathic ETV/PEA3 family (cell migration, motility), ATF6a (stress response), and VP16 (viral infection)[1].
LPPM-8 (10 and 20 μM) inhibits a Med25-dependent gene (MMP-9) in VARIO68 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 1012.28
-
Formula C50H89N7O14
-
Sequence
{(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(Glu-Asp-Leu-Leu-Leu-Leu-Val)}
-
Sequence Shortening
{(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(EDLLLLV)}
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz