XC-12
XC-12 is an orally active and potent small-molecule CD73 inhibitor (an immune checkpoint) with IC50 values of 12.36 nM and 1.29 nM against soluble and membrane-bound CD73 forms, respectively. XC-12 is promising for research of cancers.
For research use only. We do not sell to patients.
- Formula: C20H15F3N6O4
- Molecular Weight:460.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
Description
Chemical Information
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Molecular Weight 460.37
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Formula C20H15F3N6O4
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SMILES
O=C1NN=C(C=C1N2C[C@@H](CC2)OC3=CC=C(C(C(F)(F)F)=C3)C#N)C(C(N4)=O)=CNC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topics Immune Checkpoint: A Critical Target In Tumor Therapy
Immune checkpoints are inhibitory or costimulatory pathways that regulate T-cell activation, peripheral tolerance, and antitumor immune responses, and tumors can exploit these pathways to restrict effector T-cell function and establish immune escape.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XC-12 Related Classifications
HY-176203 Related Classifications
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