2. Others JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Reference Standards EGFR
  4. O-Desmethyl gefitinib (Standard)

O-Desmethyl gefitinib (Standard) is the analytical standard of O-Desmethyl gefitinib. This product is intended for research and analytical applications. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays.

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O-Desmethyl gefitinib (Standard)

O-Desmethyl gefitinib (Standard) Chemical Structure

CAS No. : 847949-49-9

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Masse moléculaire

432.88

Formule

C21H22ClFN4O3
CAS No.
SMILES

OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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O-Desmethyl gefitinib (Standard) Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Desmethyl gefitinib (Standard)847949-49-9Reference StandardsEGFREpidermal growth factor receptorErbB-1HER1GefitinibhumanplasmaCYP2D6Inhibitorinhibitorinhibit

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