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Omburtamab

(Synonyms: Mab 8H9)
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Omburtamab (Mab 8H9) is a mouse monoclonal immunoglobulin G1 (IgG1) antibody targeting B7-H3. Omburtamab specifically binds to the glycoprotein antigen B7-H3, which is widely expressed on the surface of tumor cells. As a targeting carrier for recombinant toxins, it delivers PE38 to inhibit cellular protein synthesis and induce cytotoxicity in antigen-expressing cancer cells. Omburtamab can be used in research related to glioma, breast cancer, osteosarcoma and neuroblastoma.

For research use only. We do not sell to patients.

  • Purity: 99.16%
  • CAS No.: 1895083-75-6
  • Molecular Weight:144.98 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Omburtamab
  • Experimental Validation Results for Omburtamab
  • Experimental Validation Results for Omburtamab
  • Omburtamab Chemical Structure
    Omburtamab Chemical Structure
CAS No.: 1895083-75-6
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Omburtamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Immobilized CD276/B7-H3 Protein, Human (433a.a, HEK293, His, HY-P70652) can bind Omburtamab. The EC50 for this effect is 45.43 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells with Omburtamab (HY-P99157, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Omburtamab Chemical Structure
    1/16
  • Omburtamab
  • Immobilized CD276/B7-H3 Protein, Human (433a.a, HEK293, His, HY-P70652) can bind Omburtamab. The EC50 for this effect is 45.43 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells with Omburtamab (HY-P99157, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa