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Cat. No.: HY-148558

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P2X7 receptor antagonist-3

P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC₅₀ values of 4.2 nM in humans and 6.8 nM in rats.

For research use only. We do not sell to patients.

CAS No.: 1627900-92-8
Formula: C₁₇H₁₂ClF₃N₆O
Molecular Weight:408.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

P2X7 receptor antagonist-3 Chemical Structure

CAS No.: 1627900-92-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC₅₀ values of 4.2 nM in humans and 6.8 nM in rats^[1].

IC₅₀ & Target^[1]

hP2X7R

4.2 nM (IC₅₀)

rP2X7R

6.8 nM (IC₅₀)

All P2X Receptor Isoforms :

Chemical Information

CAS No. 1627900-92-8
Molecular Weight 408.76
Formula C₁₇H₁₂ClF₃N₆O
SMILES

O=C(N1CC2=C(CC1)N(C3=NC=CC=N3)N=N2)C4=CC=CC(C(F)(F)F)=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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P2X7 receptor antagonist-3

All P2X Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

P2X7 receptor antagonist-3 Related Classifications

HY-148558 Related Classifications