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Cat. No.: HY-W895360

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pacFA

pacFA is a bifunctional fatty acid with both photocrosslinking and click chemistry properties. pacFA can be metabolically incorporated into phospholipids by cells, enabling in-situ capture, identification and imaging of protein-lipid interactions in live cells and living organisms via ultraviolet crosslinking and click reactions.

For research use only. We do not sell to patients.

CAS No.: 1262788-55-5
Formula: C₁₅H₂₄N₂O₂
Molecular Weight:264.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

pacFA Chemical Structure

CAS No.: 1262788-55-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

pacFA specifically binds to and labels the fatty acid carrier protein BSA via photoaffinity labeling, a process dependent on ultraviolet light and click chemistry, while it shows no labeling effect on lysozyme^[1].
pacFA (16 h) can be metabolically incorporated into all major classes of phospholipids in CHO and HeLa cells, but not into sphingolipids^[1].
pacFA (1-16 h) is rapidly metabolized and incorporated into neutral lipids and phospholipids in HeLa cells^[1].
pacFA (1 h) enables in-situ visualization of endoplasmic reticulum-localized protein-lipid interactions in UV-irradiated HeLa cells, while no labeling is detected under control conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

pacFA (feeding) enables visualization of protein-lipid interactions in C. elegans, with UV-dependent, tissue-specific fluorescent staining concentrated in intestinal and muscle cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1262788-55-5
Molecular Weight 264.37
Formula C₁₅H₂₄N₂O₂
SMILES

O=C(O)CCCCCCCCC1(N=N1)CCCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Haberkant P, et al. In vivo profiling and visualization of cellular protein–lipid interactions using bifunctional fatty acids. Angewandte Chemie International Edition. 2013 Apr 2;52(14):4033-8.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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