PAR-2-IN intermediate-1
Based on 2 publication(s) in Google Scholar
PAR-2-IN intermediate-1 is a drug intermediate that can be used to synthesize inhibitors of the PAR-2 signaling pathway.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.92%
- No. CAS: 1690176-75-0
- Fòrmula: C12H14ClN3O2
- Peso molecular:267.71
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PAR-2-IN intermediate-1
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Actividad biológica
Descripciòn
In Vitro
PAR-2-IN intermediate-1 (Compound Intermediate O) can be used to synthesize inhibitors of the PAR-2 signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 1690176-75-0
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Appearance Solid
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Peso molecular 267.71
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Fòrmula C12H14ClN3O2
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Color White to light yellow
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SMILES
O=C(C1=CN2N=C(Cl)C=C(C(C)(C)C)C2=N1)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Autophagy
Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. [Abstract]2025 Oct;21(10):2130-2147. PMID: 40205686 -
Cell Biochem Funct
Protease-Activated Receptor 2 Activation Provokes an Increase in Intracellular Calcium and Serotonin Secretion in a Human Enteroendocrine Cell Line. [Abstract]2025 Nov;43(11):e70132. PMID: 41139931
Solvente y solubilidad
In Vitro:
DMSO : 83.33 mg/mL (311.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7354 mL | 18.6769 mL | 37.3539 mL | 93.3846 mL |
| 5 mM | 0.7471 mL | 3.7354 mL | 7.4708 mL | 18.6769 mL | |
| 10 mM | 0.3735 mL | 1.8677 mL | 3.7354 mL | 9.3385 mL | |
| 15 mM | 0.2490 mL | 1.2451 mL | 2.4903 mL | 6.2256 mL | |
| 20 mM | 0.1868 mL | 0.9338 mL | 1.8677 mL | 4.6692 mL | |
| 25 mM | 0.1494 mL | 0.7471 mL | 1.4942 mL | 3.7354 mL | |
| 30 mM | 0.1245 mL | 0.6226 mL | 1.2451 mL | 3.1128 mL | |
| 40 mM | 0.0934 mL | 0.4669 mL | 0.9338 mL | 2.3346 mL | |
| 50 mM | 0.0747 mL | 0.3735 mL | 0.7471 mL | 1.8677 mL | |
| 60 mM | 0.0623 mL | 0.3113 mL | 0.6226 mL | 1.5564 mL | |
| 80 mM | 0.0467 mL | 0.2335 mL | 0.4669 mL | 1.1673 mL | |
| 100 mM | 0.0374 mL | 0.1868 mL | 0.3735 mL | 0.9338 mL |
PAR-2-IN intermediate-1 Related Classifications
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