2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-45

PD-1/PD-L1-IN-45 (Compound 2) is an inhibitor for PD-1/PD-L1 Interaction with EC50 of 21.8 nM.

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PD-1/PD-L1-IN-45

PD-1/PD-L1-IN-45 Estructura química

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PD-1/PD-L1-IN-45 Related Antibodies

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Descripciòn

PD-1/PD-L1-IN-45 (Compound 2) is an inhibitor for PD-1/PD-L1 Interaction with EC50 of 21.8 nM[1].

Cellular Effect
Cell Line Type Value Description References
Jurkat EC50
21.8 nM
Compound: 2
Inhibition of interaction of human PD-1 expressed in Jurkat T cells co-transfected with NFAT response element/human PD-L1 expressed in CHO-K1 cells co-expressing cell surface protein and TCR ligand preincubated with CHO-K1 cells followed by Jurkat cell addition and measured after 6 hrs by Bio-Glo reagent based luminescence microplate reader analysis
Inhibition of interaction of human PD-1 expressed in Jurkat T cells co-transfected with NFAT response element/human PD-L1 expressed in CHO-K1 cells co-expressing cell surface protein and TCR ligand preincubated with CHO-K1 cells followed by Jurkat cell addition and measured after 6 hrs by Bio-Glo reagent based luminescence microplate reader analysis
[PMID: 38894909]
Peso molecular

596.72

Fòrmula

C34H40N6O4
SMILES

CN(CCO)CC1=CN=C(C(NC2=CC=CC(C3=C(C)C(NC(C4=NC=C(CN[C@@H](C)CO)C=C4)=O)=CC=C3)=C2C)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Referencias
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PD-1/PD-L1-IN-45 Related Classifications

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Keywords:

PD-1/PD-L1-IN-45PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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Nombre del producto:
PD-1/PD-L1-IN-45
Cat. No.:
HY-161713
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