PD-1/PD-L1-IN-45
PD-1/PD-L1-IN-45 (Compound 2) is an inhibitor for PD-1/PD-L1 Interaction with EC50 of 21.8 nM.
For research use only. We do not sell to patients.
- Formula: C34H40N6O4
- Molecular Weight:596.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
21.8 nM
Compound: 2
|
Inhibition of interaction of human PD-1 expressed in Jurkat T cells co-transfected with NFAT response element/human PD-L1 expressed in CHO-K1 cells co-expressing cell surface protein and TCR ligand preincubated with CHO-K1 cells followed by Jurkat cell ad
Inhibition of interaction of human PD-1 expressed in Jurkat T cells co-transfected with NFAT response element/human PD-L1 expressed in CHO-K1 cells co-expressing cell surface protein and TCR ligand preincubated with CHO-K1 cells followed by Jurkat cell ad
|
[PMID: 38894909] |
Chemical Information
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Molecular Weight 596.72
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Formula C34H40N6O4
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SMILES
CN(CCO)CC1=CN=C(C(NC2=CC=CC(C3=C(C)C(NC(C4=NC=C(CN[C@@H](C)CO)C=C4)=O)=CC=C3)=C2C)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)