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Cat. No.: HY-186214

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PDE4-IN-36

PDE4-IN-36 is a phosphodiesterase 4 (PDE4) inhibitor with significant inhibitory activity at 10 μM. PDE4-IN-36 can be used in the research of psoriasis and atopic dermatitis.

For research use only. We do not sell to patients.

CAS No.: 3034837-81-2
Formula: C₂₃H₂₄O₈
Molecular Weight:428.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE4-IN-36 Chemical Structure

CAS No.: 3034837-81-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PDE4-IN-36 is a phosphodiesterase 4 (PDE4) inhibitor with significant inhibitory activity at 10 μM. PDE4-IN-36 can be used in the research of psoriasis and atopic dermatitis^[1].

IC₅₀ & Target^[1]

PDE4

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE4-IN-36 (Compound 8b) (0.1-10 μM) inhibits the activity of recombinant PDE4 protein, with an inhibition rate of 51-75% at a concentration of 10 μM and 1-25% at a concentration of 1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034837-81-2
Molecular Weight 428.43
Formula C₂₃H₂₄O₈
SMILES

OC(C1C2=CC(/C=C/C(O)=O)=CC(OCC)=C2OC1C3=CC(OCC)=C(C=C3)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li YM, et al. Phosphodiesterase-4 inhibitor, pharmaceutical composition comprising same, and use thereof. WO2024239762A1. WIPO. 2024-11-28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PDE4-IN-36

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PDE4-IN-36 Related Classifications

HY-186214 Related Classifications