Pentopril
Pentopril (CGS 13945) is an orally active angiotensin-converting enzyme (ACE) inhibitor. Pentopril is hydrolyzed by esterases in vivo to form an active ACE inhibitor metabolite. Pentopril can be used in the research of hypertension and congestive heart failure.
For research use only. We do not sell to patients.
- CAS No.: 82924-03-6
- Formula: C18H23NO5
- Molecular Weight:333.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Angiotensin-converting enzyme is a key peptide hydrolase that catalyzes the conversion of angiotensin Ⅰ to the vasopressor angiotensin Ⅱ and participates in the regulation of blood pressure and body fluid balance.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 82924-03-6
-
Molecular Weight 333.38
-
Formula C18H23NO5
-
SMILES
CCOC([C@H](C)C[C@@H](C)C(N1C2=CC=CC=C2C[C@H]1C(O)=O)=O)=O
-
Synonyms
CGS 13945
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pentopril Related Classifications
HY-187790 Related Classifications
Powered by Bioz