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Cat. No.: HY-115588

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Pim-1/2 kinase-IN-4

For research use only. We do not sell to patients.

CAS No.: 2314468-92-1
Formula: C₂₃H₂₅N₅O₂
Molecular Weight:403.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pim-1/2 kinase-IN-4 Chemical Structure

CAS No.: 2314468-92-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Cellular Effect

Cell Line	Type	Value	Description	References
EOL1	IC₅₀	0.002 μM Compound: 28	Antiproliferative activity against human EOL-1 cells after 72 hrs by CellTiter-Glo luminescent assay Antiproliferative activity against human EOL-1 cells after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 30624936]
KMS-12-BM	EC₅₀	0.015 μM Compound: 28	Antitumor activity against human KMS-12-BM cells xenografted in po dosed SCID-beige mouse assessed as tumor growth inhibition administered once daily for 14 days and measured twice per week Antitumor activity against human KMS-12-BM cells xenografted in po dosed SCID-beige mouse assessed as tumor growth inhibition administered once daily for 14 days and measured twice per week	[PMID: 30624936]
KMS-12-BM	ED₅₀	12 mg/kg Compound: 28	Antitumor activity against human KMS-12-BM cells xenografted in po dosed SCID-beige mouse assessed as tumor growth inhibition administered once daily for 14 days and measured twice per week Antitumor activity against human KMS-12-BM cells xenografted in po dosed SCID-beige mouse assessed as tumor growth inhibition administered once daily for 14 days and measured twice per week	[PMID: 30624936]
KMS-12-BM	IC₅₀	0.049 μM Compound: 28	Antiproliferative activity against human KMS-12-BM cells after 72 hrs by CellTiter-Glo luminescent assay Antiproliferative activity against human KMS-12-BM cells after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 30624936]
KMS-12-BM	IC₅₀	12 nM Compound: 28	Inhibition of PIM1/PIM2/PIM3 in human KMS-12-BM cells assessed as reduction in BAD phosphorylation after 110 mins by flow cytometric analysis Inhibition of PIM1/PIM2/PIM3 in human KMS-12-BM cells assessed as reduction in BAD phosphorylation after 110 mins by flow cytometric analysis	[PMID: 30624936]
OPM-2	IC₅₀	0.667 μM Compound: 28	Antiproliferative activity against human OPM2 cells after 72 hrs by CellTiter-Glo luminescent assay Antiproliferative activity against human OPM2 cells after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 30624936]
RPMI-8226	IC₅₀	0.104 μM Compound: 28	Antiproliferative activity against human RPMI8226 cells after 72 hrs by CellTiter-Glo luminescent assay Antiproliferative activity against human RPMI8226 cells after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 30624936]

Chemical Information

CAS No. 2314468-92-1
Molecular Weight 403.48
Formula C₂₃H₂₅N₅O₂
SMILES

O=C1N(C2(C)CC2)C(NC3(C)CC3)=NC4=C1C=CC=C4C5=CC6=C([C@@H](C)NC6=O)N5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

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