Poly(styrenyl acetal trehalose) (Synonyms: pSAT)

Cat. No.: HY-150502: FAQs
Data Sheet Handling Instructions

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Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule.

For research use only. We do not sell to patients.

Poly(styrenyl acetal trehalose) Chemical Structure

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Description

In Vivo

Poly(styrenyl acetal trehalose) (10 mg/kg; IV, single dosage) does not induce liver or kidney damage, and is safe in terms of acute toxicity in mice^[1].
Poly(styrenyl acetal trehalose) (1 mg/kg; IP, twice, at the 0 and 14 day) does not induce the increase of pro-inflammatory cytokines and IgG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female CD-1 mice (6 weeks, n = 6)^[1]
Dosage:	10 mg/kg
Administration:	IV, single dosage
Result:	Did not induce liver or kidney damage, and was safe in terms of acute toxicity.

Animal Model:	Female CD-1 mice (6 weeks, n = 6)^[1]
Dosage:	1 mg/kg
Administration:	IP, twice, at the 0 and 14 day
Result:	Did not lead to IgG production. Led to a slight increase in the IgM level for weeks 1 and 2 but dropped to the negative control level by week 3. Did not induce the increase of pro-inflammatory cytokines.

Formula

C₂₃H₃₄O₁₁

SMILES

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@H]2O[C@H]3[C@@H](OC(C4=CC=C(C(CC)C)C=C4)OC3)[C@H](O)[C@H]2O.[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ko JH, et al. Safety and Biodistribution Profile of Poly(styrenyl acetal trehalose) and Its Granulocyte Colony Stimulating Factor Conjugate. Biomacromolecules. 2022 Jun 29. [Content Brief]

Poly(styrenyl acetal trehalose) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poly(styrenyl acetal trehalose)pSATBiochemical Assay Reagentsprotein-polymer conjugatespolystyrenetrehaloseInhibitorinhibitorinhibit

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