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Cat. No.: HY-170603

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PRMT5-targeted fluorescent ligand-1

PRMT5-targeted fluorescent ligand-1 (Compound 7) is a PRMT5-targeted fluorescent ligand, that inhibits PRMT5 with an IC₅₀ of 29.39 nM. PRMT5-targeted fluorescent ligand-1 exhibits cell imaging activity, that exhibits good fluorescence signal in MCF-7 with an IC₅₀ of 29 nM. PRMT5-targeted fluorescent ligand-1 induces apoptosis. PRMT5-targeted fluorescent ligand-1 exhibits a maximal excitation wavelength of 438 nm and a maximal emission wavelength of 550 nm.

For research use only. We do not sell to patients.

Formula: C₄₃H₄₇N₇O₅
Molecular Weight:741.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PRMT5-targeted fluorescent ligand-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Histone Methyltransferase Isoforms :

Chemical Information

Molecular Weight 741.88
Formula C₄₃H₄₇N₇O₅
SMILES

O=C1N(C2CCN(CC(N3CC(NC4=CC5=C(C=C4)CCN(C[C@@H](O)CN6CC7=C(C=CC=C7)CC6)C5=O)C3)=O)CC2)C(C8=CC=C(N)C9=CC=CC1=C89)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ali Shah SA, et al., Shedding light on imaging cancer research: Design and synthesis of 1, 8-naphthalimide-based PRMT5-targeted fluorescent ligands. Bioorg Chem. 2025 Jan;154:108064. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PRMT5-targeted fluorescent ligand-1

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PRMT5-targeted fluorescent ligand-1

All Histone Methyltransferase Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PRMT5-targeted fluorescent ligand-1 Related Classifications

HY-170603 Related Classifications

Bioz

Keywords

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