2. PROTAC JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. PROTACs EGFR Ligands for E3 Ligase
  4. PROTAC EGFR degrader 17

PROTAC EGFR degrader 17 (Compound 35) is an EGFR PROTAC degrader with a DC50 value of 0.49 nM. PROTAC EGFR degrader 17 promotes the ubiquitination and degradation of EGFR. PROTAC EGFR degrader 17 can be used in research on various cancers, including non-small cell lung cancer.
(Pink: EGFR ligand (HY-181115); Blue: TNF Receptor ligand (HY-138793); Black: linker).

For research use only. We do not sell to patients.

PROTAC EGFR degrader 17

PROTAC EGFR degrader 17 Chemical Structure

CAS No. : 3065209-64-2

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PROTAC EGFR degrader 17 Related Antibodies

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Description

PROTAC EGFR degrader 17 (Compound 35) is an EGFR PROTAC degrader with a DC50 value of 0.49 nM. PROTAC EGFR degrader 17 promotes the ubiquitination and degradation of EGFR. PROTAC EGFR degrader 17 can be used in research on various cancers, including non-small cell lung cancer[1]. (Pink: EGFR ligand (HY-181115); Blue: TNF Receptor ligand (HY-138793); Black: linker).

IC50 & Target[1]

Cereblon

 

Molecular Weight

837.97

Formula

C46H51N11O5
CAS No.
SMILES

CN1N=CC(C2=CC(C(/N=C3N(C4)C(C=C(N5CCN(CC6CN(C7=CC(CN(C8C(NC(CC8)=O)=O)C9=O)=C9C=C7)C6)CC5)C=C%10)=C%10N/3)=O)=CC(C)=N2)=C1OC[C@@H]%11C[C@H]4CC%11
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC EGFR degrader 17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EGFR degrader 173065209-64-2PROTAC EGFR degrader17PROTAC EGFR degrader-17PROTACsEGFRLigands for E3 LigaseEpidermal growth factor receptorErbB-1HER1E3 ligase-recruiting Moietynon-small cell lung cancerInhibitorinhibitorinhibit

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PROTAC EGFR degrader 17
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HY-180917
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