CD266/TWEAK R
CD266 is the TWEAK receptor, also known as Fn14, encoded by TNFRSF12A and the smallest member of the TNF receptor superfamily. It is the exclusive receptor for TWEAK (TNFSF12) and carries a very short cytoplasmic tail that recruits TRAF proteins to activate NF-kappaB and MAPK signaling. CD266 is weakly expressed in healthy tissue but strongly induced on endothelial cells, fibroblasts and injured parenchyma, where TWEAK engagement promotes proliferation, migration, angiogenesis and inflammatory gene expression. Dysregulated TWEAK-Fn14 signaling has been implicated in chronic inflammation, tissue injury and tumor progression, and Fn14 is pursued as a therapeutic target.
