CD85c/LIR-8
CD85c, designated LIR-8, belongs to the leukocyte immunoglobulin-like receptor cluster on chromosome 19 that fine-tunes myeloid-cell activation. As an inhibitory-type member, it carries multiple extracellular immunoglobulin-like domains and cytoplasmic immunoreceptor tyrosine-based inhibitory motifs that recruit phosphatases and restrain signals from activating receptors such as Fc receptors. Like other LILR proteins it is expressed on monocytes, macrophages and dendritic cells, where HLA class I interactions contribute to self-recognition. CD85c is included in myeloid immunophenotyping panels, and altered expression has been reported in inflammatory and myeloid malignant diseases.
