Fc Receptor-like A
Fc Receptor-like A (FCRLA) is one of the more enigmatic members of the Fc receptor-like family, whose genes cluster at the human chromosome 1q21 locus alongside classical Fc gamma receptor genes. FCRLA encodes a protein with several immunoglobulin-like extracellular domains and cytoplasmic tyrosine-based motifs, and it is expressed in B-lineage cells with enrichment in germinal-center and plasma-cell compartments. Unlike FCRL1 through FCRL5, its extracellular ligand has not been clearly defined, and functional studies suggest roles in regulating B-cell activation and differentiation. FCRLA is a useful reagent for mapping Fc receptor-like family diversity and for comparative studies of B-cell malignancies.
