GRK1/RHOK
GRK1, historically named rhodopsin kinase, is the most specialised member of the visual GRK1/GRK7 subfamily. Expressed in rod photoreceptor outer segments, it phosphorylates light-activated rhodopsin on serine and threonine residues of the rhodopsin C-terminal tail, licensing arrestin binding and terminating phototransduction. Its activity toward non-visual receptors is very low, separating it from the broadly acting BARK-type kinases. A calcium-myristoyl switch operated by recoverin controls GRK1, which is N-terminally palmitoylated for membrane anchoring. Inactivating mutations in the human gene cause congenital stationary night blindness with abnormal electroretinogram responses. Recombinant GRK1 is used in phototransduction biochemistry, arrestin-recruitment assays and studies of this regulatory switch.
-
GRK1/RHOK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
