GRK5/GPRK5
GRK5 belongs to the GRK4 subfamily and is widely expressed in heart, lung, retina and brain, where it regulates agonist-activated receptors such as beta-adrenergic, muscarinic M2, angiotensin II and opioid receptors. It contains a calmodulin-binding site and a bipartite nuclear localisation signal, allowing calcium-calmodulin to inhibit its membrane-associated activity and driving GRK5 into the nucleus, where it phosphorylates histone deacetylase 5 and influences hypertrophic gene expression. GRK5 also binds tubulin and actin and displays weak DNA-dependent kinase activity. Reduced GRK5 function has been associated with Alzheimer disease models, cardiac hypertrophy and a heart-failure-linked haplotype.
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GRK5/GPRK5 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
