Nemo Like Kinase
Nemo Like Kinase (NLK) is a serine/threonine kinase named after the Drosophila gene nemo and classified within the MAP kinase superfamily, although it is not activated by conventional MAPK kinases. Instead, Wnt-1 and other stimuli trigger its activation through TAK1-mediated phosphorylation. NLK phosphorylates TCF/LEF transcription factors to attenuate Wnt-driven transcription, and it similarly modulates Notch, STAT3 and MyoD pathways. Through these effects NLK participates in mesoderm formation, neural development and tumor biology, and it has been proposed as a node where Wnt, Notch and MAPK signaling converge.
