SCYL1
SCYL1 is the founding member of the SCY1-like family, combining an N-terminal protein-kinase-like domain that functions as a pseudokinase with C-terminal tetratricopeptide-repeat-like motifs. It localizes to the cytoplasmic face of the nuclear pore and partners with RanBP2 in a complex implicated in nuclear export of selected cargos, including histone mRNAs and certain viral proteins. Although SCYL1 lacks robust catalytic activity, it contributes structurally to nucleocytoplasmic transport and Golgi organization. Biallelic SCYL1 mutations cause a human syndrome of spinocerebellar ataxia with episodic liver dysfunction and peripheral neuropathy. Recombinant SCYL1 aids studies of nuclear-pore-associated transport and this rare neurodegenerative disorder.
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SCYL1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
