STK32A/YANK1

YANK1, encoded by STK32A, is the founding member of the YANK group, a small branch of the AGC kinase family. The protein combines a conserved kinase domain with proline-rich segments carrying predicted protein-interaction motifs. Expression is highest in testis and detectable in brain and prostate. YANK family kinases have poorly defined substrates; YANK1 has been reported to interact with phosphatase regulators and to influence cell adhesion, but physiological roles remain to be established. Recombinant YANK1 provides material for characterizing this understudied AGC subfamily, including catalytic activity assays and interaction screens.