STK32C/YANK3

The third YANK-family kinase, YANK3 (STK32C), is distinguished within this AGC branch by its enrichment in brain, where transcripts are detectable in neuronal tissue. Sequence analysis indicates a conserved kinase domain related to those of YANK1 and YANK2, but YANK3 catalytic activity and regulation are largely unexplored. No disease mutations or validated substrates have been reported. Because brain-restricted paralogs often subserve neuronal signaling, YANK3 attracts interest as a potential kinase acting in neural contexts. Recombinant YANK3 supports first-pass biochemical characterization, including autophosphorylation assays and substrate identification efforts for this orphan kinase.