Limonoids from fruit of Melia toosendan and their cytotoxic activity

  • Phytochemistry. 1999 Jul;51(6):787-91. doi: 10.1016/s0031-9422(99)00115-6.
K Tada  1 ,  M Takido ,  S Kitanaka
Affiliations
  • 1. College of Pharmacy, Nihon University, Chiba, Japan.
PMID: 10389275 DOI: 10.1016/s0031-9422(99)00115-6
Abstract

Two new limonoids, toosendanal and 12-O-methylvolkensin, were isolated from the fruits of Melia toosendan Sieb. et Zucc. along with three known limonoids, meliatoxin B1, trichillin H, and toosendanin. The structures of the new limonoids were established by spectroscopic methods, with toosendanal having C-1/C-29 and C-19/C-29 acetal bridges. Both meliatoxin B1 and toosendanin exhibit cytotoxic activity against KB cells.

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