An efficient diamine.copper complex-catalyzed coupling of arylboronic acids with imidazoles

  • Org Lett. 2000 May 4;2(9):1233-6. doi: 10.1021/ol000033j.
JP Collman  1 ,  M Zhong
Affiliations
  • 1. Department of Chemistry, Stanford University, California 94305-5080, USA. [email protected]
PMID: 10810715 DOI: 10.1021/ol000033j
Abstract

[formula: see text] A novel diamine.copper complex-catalyzed intermolecular coupling of arylboronic acids (1) with imidazoles (3) is described. In the presence of a catalytic amount of [Cu(OH).TMEDA]2Cl2 (2), arylboronic acids (1) react smoothly with imidazoles (3) in dichloromethane at room temperature to give a variety of N-arylimidazoles (4) in good to excellent yields.

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