(E) -6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: synthesis, cytotoxic activity and antitumor activity

  • Bioorg Med Chem Lett. 2000 Oct 16;10(20):2301-3. doi: 10.1016/s0960-894x(00)00447-9.
Y J You  1 ,  Y Kim ,  G Y Song ,  B Z Ahn
Affiliations
  • 1. College of Pharmacy, Chungnam National University, Taejon, South Korea.
PMID: 11055343 DOI: 10.1016/s0960-894x(00)00447-9
Abstract

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED50 values, ranging from 0.1 to 0.3 microg/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%).