Isolation and structure elucidation of a novel griseorhodin

  • J Antibiot (Tokyo). 1979 Mar;32(3):197-204. doi: 10.7164/antibiotics.32.197.
R M Stroshane ,  J A Chan ,  E A Rubalcaba ,  A L Garretson ,  A A Aszalos ,  P P Roller
PMID: 110759 DOI: 10.7164/antibiotics.32.197
Abstract

Three Antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A. A second, FCRC-57-U, was found to be identical to griseorhodin C. FCRC-57-G is a new Antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new Antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.

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