Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor

  • Bioorg Med Chem Lett. 2001 Jan 22;11(2):91-4. doi: 10.1016/s0960-894x(00)00610-7.
W T Sing  1 ,  C L Lee ,  S L Yeo ,  S P Lim ,  M M Sim
Affiliations
  • 1. Medicinal and Combinatorial Chemistry Laboratory, Institute of Molecular and Cell Biology, Singapore.
PMID: 11206478 DOI: 10.1016/s0960-894x(00)00610-7
Abstract

Arylalkylidene rhodanines 2(a-d) inhibit HCV NS3 protease at moderate concentrations. They are better inhibitors of Other serine proteases such as chymotrypsin and plasmin. However, the selectivity of arylmethyliden e rhodanines (8a, 9a) with bulkier and more hydrophobic functional groups increases by 13- and 25-fold towards HCV NS3 protease respectively.

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