A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

  • Bioorg Med Chem Lett. 2001 Feb 26;11(4):541-4. doi: 10.1016/s0960-894x(00)00697-1.
X Y Yu  1 ,  J M Hill ,  G Yu ,  Y Yang ,  A F Kluge ,  D Keith ,  J Finn ,  P Gallant ,  J Silverman ,  A Lim
Affiliations
  • 1. Department of Medicinal Chemistry, Cubist Pharmaceuticals, Inc., Cambridge, MA 02139, USA. [email protected]
PMID: 11229766 DOI: 10.1016/s0960-894x(00)00697-1
Abstract

A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC50 = 5 nM (CA. ProRS) with high selectivity over the human enzyme.

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